1.风湿免疫性疾病的临床诊治和发病机制研究 支气管哮喘发病机制研究

主要学术任职 中华医学会儿科分会风湿病学组 副组长 浙江省免疫学会风湿免疫专业委员会 主任委员 浙江省医学会儿科分会风湿病学组 组长 亚太医学生物免疫学会 儿童过敏免疫风湿病分会副主委 浙江省数理医学会风湿病学分会 副主委 浙江省医学会风湿病学分会 常务委员 浙江省医师协会风湿病学分会医师协会 常务委员 获得学术奖励 浙江省医药卫生科技创新奖二等奖、省科学技术进步奖三等奖各1项（排名第一） 参编专著 1.参编.《全科医学导入式诊疗思维》.第1 版.北京:人民卫生出版社,2018. （编委） 2. 参编《妇产儿童风湿病学》人民卫生出版社，2019（编委） 主持课题8项，包括国家自然科学基金2项 1负责浙江省基础公益研究计划项目“早发性白塞氏病TNFAIP3/A20基因诊断及治疗研究”。项目批准号（LGF19H100002），起止日期2019年1月 - 2021 年12月，经费10.00 万元 2负责国家自然科学基金项目“PAK1信号调控树突状细胞归巢的机制及在哮喘中的意义”， 项目批准号(81270067)，起止日期01/2013-12/2016, 经费75万元 3负责国家自然科学基金项目“Th17、Treg细胞在DC-IL10诱导哮喘免疫耐受中的调节作用”；项目批准号（81070012）；起止日期2011.01-2012.12；33万元 4浙江省钱江人才计划项目“Treg对DC特异性免疫治疗哮喘小鼠Th17细胞表达的影响及意义”；项目批准号（2011R10028）；起止日期2011.08 ~2013.07；10万元 5负责浙江省自然科学基金项目“Th17及调节性T细胞在耐受性DC治疗哮喘中的作用机制研究”；项目批准号（Y2090339）；起止日期2010.1-2011.12；5.5万元 6负责浙江省卫生厅项目“大豆异黄酮对糖尿病甲基乙二醛水平及慢性并发症的影响及相关机制研究”；项目批准号（2008A103）；起止日期2008.07 -2010.12；3万元 7参与（排名第二）浙江省卫生厅项目“儿童重症肺炎支原体肺炎支气管肺泡灌洗液T细胞表面活化分子表达研究”；项目批准号？；起止日期2009.07 -2011.12；3万元 8rhSOD联合iNO或肺表面活性物质治疗胎粪性肺损伤的作用及机制研究：项目来源浙江省科技厅，经费12万，项目编号2004C33019，2004年01月起-2006年06月止，本人排名/总人数：1/7 9重组人超氧化物岐化酶联合NO治疗急性肺损伤的机制研究：项目来源浙江省教育厅，经费1.5万，项目编号20030304，2003年09月起-2005年07月止，本人排名/总人数：1/5 代表性期刊论文（*通讯作者）： 发表国内核心期刊50篇，国外SCI期刊33篇，以第一作者发表影响因子>4 分的SCI论文3篇。以下为近年发表的主要的SCI论文： 1.Qian X, Liu YX, Ye X, Zheng W, Lv S, Mo M, Lin J, Wang W, Wang W, Zhang X,Lu M*. Gut microbiota in children with juvenile idiopathic arthritis:characteristics, biomarker identification, and usefulness in clinicalprediction. BMC Genomics. 2020 Apr 7;21(1):286. 2.Liu YX, Qin Y, Chen T, Lu M, Qian X, Guo X, Bai Y. A practical guide to amplicon and metagenomic analysis of microbiome data. Protein Cell. 2020 May 11. 3.Zou LX, Lu MP, Jung LKL. Current status and recent advances on the use of ultrasonography in pediatric rheumatic diseases. World J Pediatr. 2020 Feb;16(1):52-59. 4.Zou LX, Zhu Y, Sun L, Ma HH, Yang SR, Zeng HS, Xiao JH, Yu HG, Guo L, Xu YP, Lu MP*. Clinical and laboratory features, treatment, and outcomes of macrophage activation syndrome in 80 children: a multi-center study in China. World J Pediatr. 2020 Feb;16(1):89-98. 5.Wu JQ, Lu MP, Reed AM. Juvenile dermatomyositis: advances in clinical presentation, myositis-specific antibodies and treatment. World J Pediatr. 2020 Feb;16(1):31-43. 6.Pan L, Lu MP, Wang JH, Xu M, Yang SR. Immunological pathogenesis and treatment of systemic lupus erythematosus. World J Pediatr. 2020 Feb;16(1):19-30. 7.Zheng Q, Lu M*. Bilateral brachial synovial cysts in systemic juvenile idiopathic arthritis: Case report and literature review. Int J Rheum Dis. 2019 Aug;22(8):1578-1581. 8.Yu MP, Xu XS, Zhou Q, Deuitch N, Lu MP*. Haploinsufficiency of A20 (HA20): updates on the genetics, phenotype, pathogenesis and treatment. World J Pediatr. 2019 Oct 5. 9.Li Y, Zheng Q, Zou L, Wu J, Guo L, Teng L, Zheng R, Jung LKL, Lu M*. Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition. Pediatr Rheumatol Online J. 2019 Jan 5;17(1):1. 10.Zheng Q, Zhu K, Gao CN, Xu YP, Lu MP*. Prevalence of Epstein-Barr virus infection and characteristics of lymphocyte subsets in newly onset juvenile dermatomyositis. World J Pediatr. 2019 Sep 23. 11.Lu M, Xu C, Zhang Q, Wu X, Tang L, Wang X, Wu J, Wu X. Inhibition of p21-activated kinase 1 attenuates the cardinal features of asthma through suppressing the lymph node homing of dendritic cells. Biochem Pharmacol. 2018 Aug;154:464-473. 12.Qian X, Gao Y, Ye X, Lu M*. Association of STAT6 variants with asthma risk: a systematic review and meta-analysis. Hum Immunol. 2014 Aug;75(8):847-53. 13.Guo L, Liu F, Lu MP*, Zheng Q, Chen ZM. Increased T cell activation in BALF from children with Mycoplasma pneumoniae pneumonia. Pediatr Pulmonol. 2015 Aug;50(8):814-9. 14.Lu MP, Ma LY, Zheng Q, Dong LL, Chen ZM. Clinical characteristics of adenovirus associated lower respiratory tract infection in children. World J Pediatr. 2013 Nov;9(4):346-9. 15.Guo LI, Chen BO, Xu B, Lu M, Ning B, Chen Z. X-linked hyper-IgM syndrome with eosinophilia in a male child: A case report. Exp Ther Med. 2015 Apr;9(4):1328-1330. 16.Huang H, Dawicki W, Lu M, Nayyar A, Zhang X, Gordon JR. Regulatory dendritic cell expression of MHCII and IL-10 are jointly requisite for induction of tolerance in a murine model of OVA-asthma. Allergy 2013; 68: 1126–1135 17.Nayyar A, Dawicki W, Huang H, Lu M, Zhang X, Gordon JR. Induction of Prolonged Asthma Tolerance by IL-10-Differentiated Dendritic Cells: Differential Impact on Airway Hyperresponsiveness and the Th2 Immunoinflammatory Response.J Immunol. 2012,189(1):72-9. 18.M. Lu*, W. Dawicki, X. Zhang, H. Huang, A. Nayyar, J. R. Gordon*. Therapeutic induction of tolerance by IL-10-differentiated dendritic cells in a mouse model of house dust mite-asthma. Allergy,2011,66(5):612-620 （IF>6.0） 19.Xu C, Zou C, Hussain M, Shi W, Shao Y, Jiang Z, Wu X, Lu M, Wu J, Xie Q, Ke Y, Long F, Tang L, Wu X. High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia. Mucosal Immunol. 2018 Sep;11(5):1306-1315. 20.Hu X, Ji X, Yang M, Fan S, Wang J, Lu M, Shi W, Mei L, Xu C, Fan X, Hussain M, Du J, Wu J, Wu X. Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis. J Bone Miner Res. 2018 May;33(5):945-958. 21.Hussain M, Xu C, Ahmad M, Majeed A, Lu M, Wu X, Tang L, Wu X. Acute Respiratory Distress Syndrome: Bench-to-Bedside Approaches to Improve Drug Development. Clin Pharmacol Ther. 2018 Sep;104(3):484-494. 22.Hussain M, Xu C, Lu M, Wu X, Tang L, Wu X. Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3226-3242. 23.Shi W, Xu C, Hussain M, Wu F, Lu M, Wu X, Tang L, Wu X, Wu J. Inhibition of Myosin Light-Chain Kinase Enhances the Clearance of Lipopolysaccharide-Induced Lung Inflammation Possibly by Accelerating Neutrophil Apoptosis. Shock. 2017 Sep;48(3):377-386. 24.Hussain M, Xu C, Ahmad M, Yang Y, Lu M, Wu X, Tang L, Wu X. Notch Signaling:Linking Embryonic Lung Development and Asthmatic Airway Remodeling. Mol Pharmacol. 2017 Dec;92(6):676-693.